ahem

diff --git a/biblio/22751100.mdwn b/biblio/22751100.mdwn
new file mode 100644 (file)
index 0000000..d0af8f6
--- /dev/null
+++ b/biblio/22751100.mdwn
@@ -0,0 +1,10 @@
+[[!meta title="Structural diversity and African origin of the 17q21.31 inversion polymorphism."]]
+[[!tag variants]]
+
+Steinberg KM, Antonacci F, Sudmant PH, Kidd JM, Campbell CD, Vives L, Malig M, Scheinfeldt L, Beggs W, Ibrahim M, Lema G, Nyambo TB, Omar SA, Bodo JM, Froment A, Donnelly MP, Kidd KK, Tishkoff SA, Eichler EE.
+
+Nat Genet. 2012 Jul 1;44(8):872-80. doi:10.1038/ng.2335
+
+Structural diversity and African origin of the 17q21.31 inversion polymorphism.
+
+[[!pmid 22751100 desc="“In conclusion, we propose that the ancestral H2′ haplotype arose in eastern or central Africa and spread to southern Africa before the emergence of anatomically modern humans (Fig. 6). Approximately 2.3 million years ago, the inversion rearranged to what we now refer as the direct orientation haplotype (H1′).”"]]

diff --git a/tags/variants.mdwn b/tags/variants.mdwn
index 98eb189d85f7ec449534492a9d9becd7efa5beb2..9bc58e5773492b0ea6b8a6a3d2f6dc0f769f9fe7 100644 (file)
--- a/tags/variants.mdwn
+++ b/tags/variants.mdwn
@@ -32,7 +32,8 @@ suppress crossovers not only inside the inversion but also close to it (within 1
 genome and calculated that it appeared ~3 million years ago, before the
 speciation of _Homo sapiens_.  Low-copy repeated sequences were found in the
 vicinity.  [[Donelly and coll., 2010|biblio/20116045]] gave a radically lower
-time estimate of 13,600 to 108,400 years.
+time estimate of 13,600 to 108,400 years, but an ancient origin was again
+supported by [[Steinberg and coll in 2012|biblio/22751100]].
 
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