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+[[!meta title="Nature. 2004 Sep 16;431(7006):308-12."]]
+[[!tag network]]
+
+Nature. 2004 Sep 16;431(7006):308-12 doi:10.1038/nature02782
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+Luscombe NM, Babu MM, Yu H, Snyder M, Teichmann SA, Gerstein M.
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+Genomic analysis of regulatory network dynamics reveals large topological changes.
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+[[!pmid 15372033 desc="Primary paper for SANDY. Distinguishes "endogenous" from "exogenous" networks, and introduces transient hubs."]]
15289483 [networks]
Monitoring 20-min intervals over 8-h and 16-h.
-15372033 [networks]
-Primary paper for SANDY. Distinguishes "endogenous" from "exogenous" networks, and introduces transient hubs.
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15229602 [genome]
Uses a hybrid melanogaster / simulans approach, to demonstrate that interspecific variations in gene expression mostly originate from modification of cis-regulation.
15314228 [genome]
Codon usage has been preserved during human-mouse evolution.
-15343339 [networks]
-Defines "condition invariant", "condition enabled", "condition expanded", and "condition altered" transcription factor binding behaviour.
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15328367 [alternative promoters]
Alternative promoters which transcribe variants with different translational efficiencies.
15239836 [mining]
To take into account the discrete distributin of SAGE tags.
-15598746 [networking]
-Two types of subgraphs are distinguished. Type I are abundant and form giant componants. Type II are rare and form clusters. The belonging to class I and II depend on global network propertiesm and vice-versa.
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15588312 [mining]
Trains learning machines with a GO categor, and interrogates a 40 000 genes x 55 tissues matrix of microarray results.
15990270 [enhancers] [not read]
Conserved in mammals but not in chicken.
-15603590 [networks]
-Based on a transcriptional regulatory network which contains only 20% of the E. coli genes. Shows that there is no feedback loop at a purely transcriptional level. As a consequence, eht network can be represented by five hierarchical layers.
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15967424 [enhancers] [not read]
This one is conserved between human and mouse. Not tested in ZF.
15961632 [genome]
A lot of proximal promoters are histone-free. This includes genes which are inactive, but are ready to react.
-15598744 [networks]
-Uses Self-Organising Maps to aggregate the transcriptome of B cells into 12 megamodules.
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16024824 [enhancers]
The ultraconserved elements in the Irx clusters are transcription enhancers.
16094371 [networks]
Functional validation.
-15608232 [networks]
-Comprehensive database featuring coexpression, co-occurence in the litterature, genomic neighbourhood in addition to high-throughput informations as protein-protein interaction.
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16077029 [misc]
Suppressive PCR allows the use of one gene-specific primer, and one random primer. Asymetric cloning is the second safeguard against background.