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diff --git a/biblio/33972781.mdwn b/biblio/33972781.mdwn
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+[[!meta title="Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits."]]
+[[!tag variants PRDM9]]
+
+Beyter D, Ingimundardottir H, Oddsson A, Eggertsson HP, Bjornsson E, Jonsson H, Atlason BA, Kristmundsdottir S, Mehringer S, Hardarson MT, Gudjonsson SA, Magnusdottir DN, Jonasdottir A, Jonasdottir A, Kristjansson RP, Sverrisson ST, Holley G, Palsson G, Stefansson OA, Eyjolfsson G, Olafsson I, Sigurdardottir O, Torfason B, Masson G, Helgason A, Thorsteinsdottir U, Holm H, Gudbjartsson DF, Sulem P, Magnusson OT, Halldorsson BV, Stefansson K.
+
+Nat Genet. 2021 Jun;53(6):779-786. doi:10.1038/s41588-021-00865-4
+
+Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits.
+
+[[!pmid 33972781 desc="”We generated [long read sequencing] data from 3,622 Icelanders and identified a median of 22,636 SVs per individual (a median of 13,353 insertions and 9,474 deletions).”  “We did not attempt to discover translocations and inversions.“  “We found more SVs, particularly TR SVs, near telomeres, a reflection of the sequence content of telomeres and the high mutation rate of TRs”  “The ZnF domain of PRDM9 is the DNA-binding domain, and the SV alleles thus introduce alterations in the DNA-binding motif of PRDM9 and consequently change the locations of meiotic recombination57,58. All the different ZnF-motif lengths showed a strong association with the location of crossovers as measured by the fraction of crossovers that occur in recombination hotspots.”"]]

diff --git a/tags/variants.mdwn b/tags/variants.mdwn
index 86f3ec85aa14f86bf3d87ee33de5270573b5c7d1..6971bd680ba2576b8f7942420bb15ef06d6d9dfb 100644 (file)
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 [[!meta title="pages tagged variants"]]
 
-[[!inline pages="tagged(variants)" actions="no" archive="yes"
-feedshow=10]]
+_in progress_
+
+Long read sequencing data from 3,622 Icelanders identified a median of 22,636
+SVs per individual (insertios: 13,353; deletions: 9,474) [[Beyter and coll, 2021|biblio/33972781]].
+
+[[!inline pages="tagged(variants)" limit=0]]