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+[[!meta title="Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase."]]
+[[!tag reverse-transcription]]
+
+Proc Natl Acad Sci U S A. 1989 Nov;86(21):8343-7 doi:10.1073/pnas.86.21.8343
+
+Perrino FW, Preston BD, Sandell LL, Loeb LA.
+
+Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase.
+
+[[!pmid 2479023 desc="HIV-1 RT can extend A-mismatches with various efficiencies: A:C >> A:A > A:G."]]

diff --git a/tags/reverse_transcription.mdwn b/tags/reverse_transcription.mdwn
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@@ -127,7 +127,9 @@ nucleotide as a template.
 
 ### Reverse-transcriptases tolerate terminal mismatches
 
- - Reported by [[Mizuno et al., 1999|biblio/9973624]].
+ - HIV-1 RT can extend A-mismatches with various efficiencies: A:C >> A:A > A:G
+   ([[Perrino and coll., 1898|biblio/2479023]]). 
+ - Reported by [[Mizuno et al., 1999|biblio/9973624]] for double-mismatches and MMLV.
  - Utilised in [[Arnaud et al., 2016|biblio/27071605]] to reduce priming or
    ribosomal or hemoglobin RNA.
  - Specificity of RT nevertheless increases with reaction temperature.  For