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+[[!meta title="Genome rearrangement by replication-directed translocation."]]
+[[!tag bacteria variants]]
+
+Tillier ER, Collins RA
+
+Nat Genet. 2000 Oct;26(2):195-7. doi:10.1038/79918
+
+Genome rearrangement by replication-directed translocation.
+
+[[!pmid 11017076 desc="X-shaped patterns in whole-genome comparisons dot plots.
+“Single-gene inversions occurred at 12 of 44 boundaries [of repositioned blocks
+of genes] identified in _Chlamydia_, compared with only 13 local inversions
+adjacent to any of the 643 genes not at a boundary” Proposes that
+origin-centered inversions caused by replication forks can generate the
+patterns."]]
human/mouse comparisons, median length 814.
In bacteria, rearrangements have been reported to generate a X-shaped pattern
-in dot-plots by [[Eisen and coll (2000)|biblio/11178265]]. The authors suggest
-that the patterns are generated by inversions centered on origins and termini.
-The prevalence of this phenomenon was confirmed by [[D'Iorio and Dewar,
-2022|biblio/36261227]].
+in dot-plots by [[Eisen and coll (2000)|biblio/11178265]] and [[Tillier and
+Collins (2000)|biblio/11017076]]. Both reports suggest that the patterns are
+generated by inversions centered on origins and termini. The prevalence of
+this phenomenon was confirmed by [[D'Iorio and Dewar, 2022|biblio/36261227]].
### Mechanism